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5F-AKB-48, or 5F-APINACA is a synthetic cannabinoid drug containing a substituted indazole group. This indazole moeity is substituted at R1 with a fluoropentyl chain, a substitution shared with 5F-PB-22.And the indazole is substituted at R3 with a carboxamide group. This group is N-substituted at its terminal amine group with an adamantane group. This group consists of four fused cyclohexane rings in a unique structure called a diamondoid. 5F-AKB-48 is an analog of STS-135 in which the core indole structure is substituted with an indazole base
5F-APINACA was first made in South Korea. It is expected to be a potent agonist of the CB1 receptor and CB2 receptor.Its metabolism has been described in literature.
Structurally 5F-APINACA closely resembles cannabinoid compounds from patent. WO 2003/035005 but with a 5-fluoropentyl chain on the indazole 1-position, and 5F-AKB-48 falls within the claims of this patent. It is very similar to the corresponding pentanenitrile and 4-chlorobutyl compounds.
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